HistoryThis section has been translated automatically.
DefinitionThis section has been translated automatically.
Amiodarone (Amiodarex®, Amiohexal®, Cordarex®, Tachydarone®) is an iodinated benzofuran derivative, a calcium antagonist used as a class III antiarrhythmic agent. Dermatogenic ADRs are slate grey hyperpigmentation on light-exposed skin areas.
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Occurrence/EpidemiologyThis section has been translated automatically.
0.5-10% of patients treated with amiodarone show dose-dependent discoloration. 0.1-0.3% of patients develop full vision.
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HistologyThis section has been translated automatically.
Plaque-like perivascular agglomerates of yellow-brown colour complexes (lipofuscin) in the upper dermis. The "degeneration pigment" lipofuscin, a protein and cholesterol-containing mixture of lipo- and argentophilic pigments and is absorbed by lyosomes and histiocytes. Extracellular pigment does not occur.
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LiteratureThis section has been translated automatically.
- Dereure O (2001) Drug-induced skin pigmentation. Epidemiology, diagnosis and treatment. At J Clin Dermatol 2: 253-262
- Dissemond J et al (2003) Hyperpigmentation of the face. dermatologist 54: 994-998
- Drosner M, Worret WI, Marquart KH (1990) Amiodarone hyperpigmentation. Nude Dermatol 16: 67-69
- Korting HC, Kolz R, Schmoeckel C, Balda BR (1981) Amiodarone pigmentation. A rare but typical drug side effect. dermatologist 32: 301-305
- Levine N (2004) Grayish discoloration in symmetrical pattern on hands. Drug used for cardiac condition may produce skin problem. Geriatrics 59: 32
- Vestesaeger M, Gillot G, Rasson G (1967) Etude clinique d'une nouvelle medication anti-angoreuse. Acta Cardiol 22: 483-500
Incoming links (4)
Amiodarone; Base gel emulsifying hydrophobic (dac); Cutis aurantiasis; Dyschromia;Outgoing links (4)
Base gel emulsifying hydrophobic (dac); Camouflage; Hyperpigmentation; Light protection;Disclaimer
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