Agranulocytosis D70.x

Author: Prof. Dr. med. Peter Altmeyer

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Last updated on: 29.10.2020

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Definition
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Strong reduction to absence of granulocytes of different genesis.

Etiopathogenesis
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In addition to a genetically determined form, acquired toxic or allergy-induced agranulocytosis can be distinguished from different drugs.

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Clinical features
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Fever, chills, vomiting, tachycardia, circulatory collapse. Necrotizing and gangrenous skin symptoms, especially on the orifices, aphthoid ulcerations of the mucous membrane, s.a. Angina agranulocytotica, possibly petechial haemorrhages, purpura.

Histology
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Nonspecific necrotizing inflammation.

Diagnosis
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Blood count: leukocytopenia, granulocytopenia.

External therapy
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Antiseptic mouthwashes R255 R045 R066, brushes with aqueous 0.5% methylrosanilinium chloride solution, solutions containing benzocaine(e.g. Dolo-Dobendan solution, anaesthetic throat tablets) for pain relief.

Internal therapy
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Substitution in cooperation with the internist.

Disclaimer

Please ask your physician for a reliable diagnosis. This website is only meant as a reference.

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Last updated on: 29.10.2020