DefinitionThis section has been translated automatically.
ClassificationThis section has been translated automatically.
Adhesion molecules (CAM) include:
- Immunoglobulin superfamily (so called because the individual members have structural similarities to immunoglobulins. They are expressed by the vascular endothelium and bind to integrins on the cell surface of leukocytes). These include:
- ICAM (Intercellular Cell Adhesion Molecule)
- VCAM (Vascular Cell Adhesion Molecule)
- PECAM (Platelet-Endothelial Cell Adhesion Molecule).
General informationThis section has been translated automatically.
Adhesion molecules usually consist of an intracellular, a transmembrane and an extracellular domain. The actual adhesion is mediated by the extracellular domain. The intracellular domain is often used for signal transduction into the interior of the cell. Due to the important role that adhesion molecules play in leukocyte migration, they are interesting targets for novel therapies.
LiteratureThis section has been translated automatically.
- Carlos TM et al (1994) Leukocyte-Endothelial Adhesion Molecules. Blood 84: 2068-2101
- Springer TA (1995) Traffic signals on endothelium for lymphocyte recirculation and leukocyte emigration. Ann Rev Physiol 57: 827-872
- Trzpis M et al(2007) Epithelial cell adhesion molecule: more than a carcinoma marker and adhesion molecule. At J cathode 171: 386-95