DefinitionThis section has been translated automatically.
Transmembrane glycoproteins from the cadherin group. In the skin, desmoglein 1 and desmoglein 3 are predominantly expressed in intercellular connections and act as adhesion molecules in desmosomes. Desmoglein 1 is expressed in all skin layers in adults, desmoglein 3 predominantly in the stratum basale and stratum granulosum.
DSG3 is a central autoantigen in pemphigus vulgaris.
Prof. Dr. med. Peter Altmeyer