Author: Prof. Dr. med. Peter Altmeyer

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Last updated on: 29.10.2020

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C-C motif chemokine receptor 1.; CD191; CKR1; CKR-1; CMKBR1; HM145; MIP1aR; SCYAR1; (see also CD classification) CCR1

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CCR1, or C-C chemokine receptor type 1, is a receptor protein encoded by the CCR1 gene in humans. CCR1 is a member of the beta-chemokine receptor family, which belongs to the G-protein-coupled, transmembrane chemokine receptors. The CCR1 gene encoding CCR1 is associated with a family of genes including CCR2, CCRL2, CCR3, CCR5 and CXCR1 located on chromosome 3p.

General information
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The CCR1 receptor is expressed by different cells in different densities, such as neutrophil and eosinophil granulocytes, monocytes, T cells, osteoclasts.

The activity of the receptor influences inflammatory reactions via leukocyte chemotaxis and via a balance of cytokine interactions.

The ligands that bind to this receptor are the chemokines CCL3 (also MIP-1 alpha), CCL5 (also RANTES), CCL7 (also MCP-3), CCL9 and CCL23 (also MPIF-1).

CCR1 antagonists could play a role in rheumatoid arthritis (M06.99) and other autoimmunological diseases and in the treatment of bone lesions in multiple myeloma (C90.00). They have not yet achieved clinical significance.

CCR1 "knock-out studies" have demonstrated an important role of the CCR1 receptor in inflammatory responses to viral and parasitic infections.

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  1. Saeki T et al (2003) CCR1 chemokine receptor antagonist. Curr Pharm Des 9:1201-1208.
  2. Zimmermann HW et al (2014) CCR1 and CCR2 antagonists. Curr Top Med Chem 14:1539-1552.
  3. Vallet S et al (2011) CCR1 as a target for multiple myeloma. Expert Opinion Ther Targets 15:1037-1047.

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Ccl9; CD classification;


Last updated on: 29.10.2020