Purpura thrombocytopenic M31.1

Polyätiological, microangiopathic, mostly small spotted purpura (petechiae) caused by thrombocytopenia of varying aetiology and severity.

The causes of thrombocytopenia include:

• educational disorders:
  • Diminished megakaryocytopoiesis:
    • Congenital
    • Acquired: E.g. by drugs, radiotherapy, chemicals, viruses, bacterial infections.
    • Displacement: E.g. by bone marrow carcinosis, leukemia, malignant lymphomas (e.g. plasmocytoma), osteomyelofibrosis.
  • Ineffective thrombocytopoiesis: e.g. Wiskott-Aldrich syndrome.
• Increased degradation or consumption:
  • Immunological:
    • Primary autoantibody formation: e.g. idiopathic thrombocytopenic purpura.
    • Secondary autoantibody production: e.g. drugs, collagenosis, immune complex diseases, antiphospholipid antibody syndrome).
  • Non-immunological:
    • E.g. disseminated intravascular coagulation.
• distribution disorders:
  • E.g. platelet pooling in the spleen for splenomegaly.

Hemorrhages, ecchymoses, suggestions- Capillary damage is also common.

• Varies depending on the triggering cause.
• Avoid a triggering drug. Depending on the clinic and platelet count, systemic glucocorticoids are indicated, e.g. prednisone (e.g. Decortin) initial 100 mg/day, gradual reduction according to clinic.
• The treatment of thrombocytopenia is a treatment to be carried out under internal control.

The thrombocytopenic purpura is not to be confused with the Moschcowitz syndrome, the thrombotic-thrombocytopenic purpura.