Purpura thrombocytopenic M31.1

Author: Prof. Dr. med. Peter Altmeyer

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Last updated on: 29.10.2020

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Polyätiological, microangiopathic, mostly small spotted purpura (petechiae) caused by thrombocytopenia of varying aetiology and severity.

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The causes of thrombocytopenia include:

  • educational disorders:
    • Diminished megakaryocytopoiesis:
      • Congenital
      • Acquired: E.g. by drugs, radiotherapy, chemicals, viruses, bacterial infections.
      • Displacement: E.g. by bone marrow carcinosis, leukemia, malignant lymphomas (e.g. plasmocytoma), osteomyelofibrosis.
    • Ineffective thrombocytopoiesis: e.g. Wiskott-Aldrich syndrome.
  • Increased degradation or consumption:
    • Immunological:
      • Primary autoantibody formation: e.g. idiopathic thrombocytopenic purpura.
      • Secondary autoantibody production: e.g. drugs, collagenosis, immune complex diseases, antiphospholipid antibody syndrome).
    • Non-immunological:
      • E.g. disseminated intravascular coagulation.
  • distribution disorders:
    • E.g. platelet pooling in the spleen for splenomegaly.

Clinical features
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Hemorrhages, ecchymoses, suggestions- Capillary damage is also common.

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  • Varies depending on the triggering cause.
  • Avoid a triggering drug. Depending on the clinic and platelet count, systemic glucocorticoids are indicated, e.g. prednisone (e.g. Decortin) initial 100 mg/day, gradual reduction according to clinic.
  • The treatment of thrombocytopenia is a treatment to be carried out under internal control.

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The thrombocytopenic purpura is not to be confused with the Moschcowitz syndrome, the thrombotic-thrombocytopenic purpura.

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Last updated on: 29.10.2020