Heparinoids

Heparinoids are proteoglycans, which are mainly found in the endothelium, but also in connective tissue structures. They act similarly to heparin (but are much less effective) by enhancing antithrombin III activity and inhibiting thrombin and activated factor X.
Heparinoids include
:- heparan sulphate -
dermatan sulphate -
danaparoid (organaran
) - pentosan polysulphate.

heparan sulphate, dermatan sulphate

Heparan sulfate has a molecular weight of 33,000 D. It contains no D-glucosamine, but D-galactosamine. It does not act via the AT-III, but it inactivates thrombin via the feparin cofactor II by accelerating the action of the heparin cofactor II by a thousand-fold.

1. HA Neumann (2014) The coagulation system. ABW-Scientific Publisher GmbH Berlin