Factor xi

Author: Prof. Dr. med. Peter Altmeyer

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Last updated on: 29.10.2020

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Plasmathrombinplastin Antectecent (PTA); Rosenthal factor

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Factor XI, or F-XI, is a gamma-globulin with a molecular weight of 140,000 - 160,000 D and consists of two identical chains connected by disulfide bonds. In the plasma, F-XI circulates as a complex with high molecular weight kininogen (HMWK). The plasma concentration is 2-7 ug/ml. The factor XIa activates F-IX to F-IXa in the intrinsic system.

General information
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Rosenthal described this factor in 1952, when he discovered it when he examined the plasma of two siblings who did not have very pronounced hemorrhagic diathesis. This defect was frequently found in Japanese and Ashkenazi Jews. The basis is an autosomal defect inherited from both parents.

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  1. HA Neumann (2014) The coagulation system. ABW-Wissenschaftsverlag GmbH Berlin p. 64.


Last updated on: 29.10.2020