Coagulation inhibitors

Author:Prof. Dr. med. Peter Altmeyer

Last updated on: 29.10.2020

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DefinitionThis section has been translated automatically.

The coagulation system is antagonized by coagulation inhibitors. This prevents the coagulation from running out of control. It is a no less complicated system. Antagonists of the coagulation system or activators of the inhibitory coagulation system act on activators of the coagulation system.

Effect of the inhibitory system on the clot activators
Clotting antagonist	Substrate
AntithrombinIII	Thrombin, Xa, IXa, VIIa, XIa, XIIa
heparin cofactor II	Thrombin
Protein C, Protein S	Va, VIIIa, PAI
TFPI	Xa, VIIa
alpha-1-antitrypsin	Thrombin, Xa, XIa, aPC, plasmin, kallikrein
C1 inhibitor	Kallikrein, plasmin, XIIa, XIa
alpha-2-macroglobulin	Thrombin, Xa, aPC, plasmin, kallikrein

LiteratureThis section has been translated automatically.

HA Neumann (2014) The coagulation system. ABW-Wissenschaftsverlag GmbH Berlin p. 94.

Authors

Last updated on: 29.10.2020

Author: Prof. Dr. med. Peter Altmeyer