Tissue factor pathway inhibitor

Author:Prof. Dr. med. Peter Altmeyer

All authors of this article

Last updated on: 29.10.2020

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Synonym(s)

TFPI

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DefinitionThis section has been translated automatically.

protein that is predominantly absorbed at the endothelia and plays an important role in clotting.TFPI binds factor Xa to a complex that antagonizes the tissue thromboplastin factor VIIa complex. In addition, factor X activation is stopped. The molecular weight is between 34-40 kD. The half-life is 100 minutes.
In plasma, TFPI is bound to lipoproteins. Only about 10% is present in free form. The synthesis of the tissue factor pathway inhibitor takes place in the endothelium.

Note(s)This section has been translated automatically.

A recombinant TFPI (tifacogin) was tested as an anticoagulant for the therapy of sepsis. It was not used in the clinic because there was a significant increase in the bleeding rate.

LiteratureThis section has been translated automatically.

  1. HA Neumann (2014) The coagulation system. ABW-Wissenschaftsverlag GmbH Berlin S. 100f.

Authors

Last updated on: 29.10.2020

Author: Prof. Dr. med. Peter Altmeyer