DefinitionThis section has been translated automatically.
The coagulation system is antagonized by coagulation inhibitors. This prevents the coagulation from running out of control. It is a no less complicated system. Antagonists of the coagulation system or activators of the inhibitory coagulation system act on activators of the coagulation system.
| Clotting antagonist | Substrate |
| AntithrombinIII | Thrombin, Xa, IXa, VIIa, XIa, XIIa |
| heparin cofactor II | Thrombin |
| Protein C, Protein S | Va, VIIIa, PAI |
| TFPI | Xa, VIIa |
| alpha-1-antitrypsin | Thrombin, Xa, XIa, aPC, plasmin, kallikrein |
| C1 inhibitor | Kallikrein, plasmin, XIIa, XIa |
| alpha-2-macroglobulin | Thrombin, Xa, aPC, plasmin, kallikrein |
LiteratureThis section has been translated automatically.
- HA Neumann (2014) The coagulation system. ABW-Wissenschaftsverlag GmbH Berlin p. 94.
Prof. Dr. med. Peter Altmeyer