Coagulation inhibitors

Author: Prof. Dr. med. Peter Altmeyer

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Last updated on: 29.10.2020

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The coagulation system is antagonized by coagulation inhibitors. This prevents the coagulation from running out of control. It is a no less complicated system. Antagonists of the coagulation system or activators of the inhibitory coagulation system act on activators of the coagulation system.

Effect of the inhibitory system on the clot activators
Clotting antagonist Substrate
AntithrombinIII Thrombin, Xa, IXa, VIIa, XIa, XIIa
heparin cofactor II Thrombin
Protein C, Protein S Va, VIIIa, PAI
alpha-1-antitrypsin Thrombin, Xa, XIa, aPC, plasmin, kallikrein
C1 inhibitor Kallikrein, plasmin, XIIa, XIa
alpha-2-macroglobulin Thrombin, Xa, aPC, plasmin, kallikrein

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  1. HA Neumann (2014) The coagulation system. ABW-Wissenschaftsverlag GmbH Berlin p. 94.


Last updated on: 29.10.2020