DefinitionThis section has been translated automatically.
Generic term for a chronic vascular disease with an intermittent or uniformly progressive course that can lead to organic stenosis or obliteration of the aorta and the arteries supplying the extremities. The diagnosis of a chronic arterial occlusive disease requires information on its localization and severity.
Chronic peripheral arterial occlusive disease is accompanied by thickening, hardening and narrowing of the vessel wall due to the accumulation of lipids, proteins and calcium. Secondary ulceration of atheromatous plaques, subintimal bleeding and localized thrombosis. Occurrence of clinical symptoms with at least 50% narrowing of the vascular lumen. Dermatologically relevant is especially the chronic arterial occlusive disease of the legs.
Occurrence/EpidemiologyThis section has been translated automatically.
With a share of >50%, cerebral (14.3%), peripheral (17.9%) and cardiac (18.1%) vascular processes are the most common diseases in industrialized countries. Compared to patients without PAD, patients with PAD have a 3-5 times higher cardiovascular mortality. The risk of apoplexy is 2 times higher.
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EtiopathogenesisThis section has been translated automatically.
Chronic peripheral arterial occlusive disease is of arteriosclerotic origin in > 90% of cases.
TherapyThis section has been translated automatically.
LiteratureThis section has been translated automatically.
- Gargiulo R et al (2015) Cardiovascular disease and chronic kidney disease. Dis Mon 61:403-413.
- Hankey GJ et al (2006) Medical treatment of peripheral artery disease. JAMA 295: 547-556
- Kario K (2016) Systemic Hemodynamic Atherothrombotic Syndrome and Resonance Hypothesis of Blood Pressure Variability: Triggering Cardiovascular Events. Korean Circ J 46:456-467.
- Ozaki Y et al (2015) Inflammatory Biomarkers in Peripheral Artery Disease: Diagnosis, Prognosis, and Therapeutic Challenges. Curr Med Chem 22:2744-2753.
- Rhee SY et al (2015) Peripheral Arterial Disease in Patients with Type 2 Diabetes Mellitus. Diabetes Metab J 39:283-290.
- S3-Guideline Peripheral Arterial Occlusive Disease (PAVK) of the German Society for Angiology - Society for Vascular Medicine (DGA). In: AWMF online
Incoming links (11)Alprostadil; Alprostadil; Aortic bifurcation syndrome; Arterial occlusive disease; Arterial occlusive disease peripheral; Chronic arterial occlusive disease; Fountain rené; Gangraena arteriosclerotica; Mixed ulcus cruris; Prostavasin; ... Show all
Outgoing links (1)Arterial occlusive disease chronic of the extremity arteries;
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