Alprostadil
Definition
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Prostaglandin derivative.
Half-life
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0,08–0,16 h
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Indication
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Peripheral arterial occlusive disease in stage III and IV, see also arterial occlusive disease, chronic.
Dosage and method of use
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Gradual dosage starting with 20 μg/day Alprostradil in 50-250 ml NaCl 0.9% slowly over at least 1 hour i.v., increase the dose to max. 60 μg/day.
Notice! In patients with heart failure, coronary heart disease, kidney dysfunction or peripheral oedema, the infusion volume should not exceed 50-100 ml/day!
Undesirable effects
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Temperature rise, confusion, cerebral seizures, RR drop, tachycardia, arthralgia, flush, sweating, chills, fever, leukopenia, leukocytosis, hyperostosis of the long bones, acute pulmonary edema or heart failure. In the infused extremity: pain, erythema, redness.
Interactions
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s. Table 1.
Contraindication
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Pregnancy, lactation, heart failure, cardiac arrhythmia, CHD, 6 months after a heart attack, pulmonary edema, severe COPD, liver disease, acute bleeding.
Preparations
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Prostavasin, Caverject, Muse, Minprog
Tables
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Main interactions of Alpostradil
Antihypertensives |
RR waste |
Anticoagulants |
Bleeding tendency ↑ |
Platelet aggregation inhibitor |
Bleeding tendency ↑ |
Vasodilators |
mutual effect ↑ |
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Prof. Dr. med. Peter Altmeyer