Angiomatosis diffuse cutaneous D18.0

Rare, acquired, benign, skin-limited vascular proliferations with painful, often centrally exuded plaques and diffuse infiltrative growth pattern.

Solitary or multiple, painful, often centrally ulcerated, brownish-livid, blurred, bizarre or flame-like plaques. The lesions develop subacutely and spontaneously and can regress rapidly even without therapy. They are often found in the vicinity of surgical scars or dialysis shunts; also in areas with chronic venous insufficiency.

Dense network of regularly structured capillary vessels that run through the entire corium. The vessels are formed by CD31- and CD34-positive endothelia and are surrounded by smooth muscle actin-positive pericytes in a cuff-shaped manner. Glomerular vascular structures and atypical endothelial mitoses are absent.

1. Kim S et al (2002) Diffuse dermal angiomatosis: a variant of reactive angioendotheliomatosis associated with peripheral vascular atherosclerosis. Arch Dermatol 138: 456-458
2. Kimyai-Asadi A (1999) Diffuse dermal angiomatosis: a variant of reactive angioendotheliomatosis associated with atherosclerosis. J Am Acad Dermatol 40: 257-259
3. Krell JM et al (1994) Diffuse dermal angiomatosis. A variant of reactive cutaneous angiomatosis. J Cutan catheter 21: 363 - 370
4. Kutzner H et al (2002) Diffuse dermal angiomatosis. Dermatologist 53: 808-812
5. Pichardo RO et al (2002) What is your diagnosis? Diffuse dermal angiomatosis secondary to anticardiolipin antibodies. At J Dermatopathol 24: 502-503