Griseofulvin

Antimycotic. Out of commerce in Germany for economic reasons! Can be imported as a single import according to §73 AMG)

• Cream: Apply 1-3 times/day to the affected skin areas.
• Systemic: 0.5-1 g/day for 3 months p.o., children < 14 years: 10-20 mg/kg bw/day (equivalent to 1-3.5 tablets of a preparation containing 125 mg griseofulvin); treatment duration: 4-8 weeks. Take unchewed with a fatty meal with liquid.

• Topical: Paragroup allergy.
• Systemic: nervousness, gastrointestinal problems, headache, fatigue, xerostomia, blood count changes (leukopenia, neutropenia, monocytosis).

Notice! Under griseofulvin, check the blood count twice in the first month of treatment, later every 2-3 months. Due to potential teratogenicity, effective contraception should be used, whereby the effect of oral contraceptives is reduced. Men should not conceive children during treatment and up to 6 months afterwards! Hepatotoxicity!

Notice! Caution in case of known penicillin allergy (griseofulvin is produced by Penicillium species).

1. Mayser P et al (2020) S1 guideline Tinea capitis. JDDG 18: 161-181

2. Seebacher C et al (2006) Tinea capitis. J Dtsch Dermatol Ges 4: 1085-1091

Significant interactions of griseofulvin