Vine leaves

Authors: Prof. Dr. med. Peter Altmeyer, Prof. Dr. med. Martina Bacharach-Buhles

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Last updated on: 29.10.2020

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Synonym(s)

Folia vitis viniferae; Folia viti viniferae; red vine leaves; Vine leaves; Vitis viniferia folium

Definition
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Extracts of red vine leaves are used as a phytotherapeutic agent for the treatment of chronic venous insufficiency (see below venous remedies). Red vine leaves contain various flavonoids with the main representative quercetin-3O-beta-glycoside. It also contains tatrate, wine, apples, succinic acid and tannins.

Pharmacodynamics (Effect)
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Known in naturopathy as blood circulation stimulating, anti-edematous, anti-inflammatory and "vitalizing".

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Indication
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Varices (I83.9), chronic venous insufficiency (I87.2), leg edemas.

Dosage and method of use
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  • Peroral: 180-360 mg p.o. once/day before breakfast. In a 12-week randomized, double-blind, placebo-controlled study, the efficacy of Vitis vinifera in a dosage of 360 and 720 mg was evaluated in 260 patients. Both dosages reduced lower leg edema to the same extent as compression stockings.
  • Cream: Apply 1-2 times/day thinly to the skin and massage in.

Standard concentration
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Cream: 2-3%.

Preparations
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Antistax extra vein tablets, Antistax vein capsules, Antistax vein cream

Note(s)
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Medically effective in red vine leaf extract is a mixture of different flavone-glycosides and flavone-glucuronides (e.g. quercetin-glucuronide, isoquercitrin).

Literature
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  1. Kiesewetter H et al (2000) Efficacy of orally administered extract of red vine leaf AS 195 (folia vitis vinifera) in chronic venous insufficiency (stages I-III). A randomized, double blind, placebo-controlled trial. Pharmaceutical research 50: 109-117