DefinitionThis section has been translated automatically.
Petroselini herba or radix, also called parsley herb or parsley root, is a drug used in herbal medicines for the prevention of kidney gravel and as part of a flushing therapy in diseases of the draining urinary tract.
Commission e-monograph: irrigation in diseases of the urinary tract; renal gravel.
IngredientsThis section has been translated automatically.
Parsley contains flavonoids (1,9 to 5,6 %): apiin, luteolin and chrysoeriol derivatives. Other ingredients are essential oil (1.2%); myristicin (usually the main component), apiol and elemicin at concentrations up to 90%; coumarin, bergapten, 1% chlorophyll, xanthotoxin, psoralen, imperatorin and isopimpinellin.
The root contains the following ingredients: flavonoids (0.2 to 1.3%), about 0.1% essential oil, (main components apiol, beta-pinene and myristicin), small amounts of coumarin, oxypeucedanine, bergapten (less than 10 ppm) and imperatorin.
Furthermore, both the root and the herb contain polyins and terpenes.
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Field of application/useThis section has been translated automatically.
Petroselini herba or radix is used for the prevention of renal gravel and as part of a flushing therapy for diseases of the urinary tract.
DosageThis section has been translated automatically.
The daily dosage is 6 g of the drug.
Undesirable effectsThis section has been translated automatically.
In rare cases an allergic skin or mucous membrane reaction may occur. In addition, light-skinned persons may experience phototoxic reactions caused by furanocoumarins.
ContraindicationThis section has been translated automatically.
It should not be taken during pregnancy, in the case of existing inflammatory kidney diseases or in the case of oedema due to restricted heart or kidney activity.
InteractionsThis section has been translated automatically.
There are no known interactions with other drugs.
Note(s)This section has been translated automatically.
During a flushing therapy, care must be taken to ensure a sufficient fluid intake of 2L/day.
The distilled oil of the root is no longer used for toxicological reasons (negative monogrpahy of Commission E). This also applies to the pure apiol-rich (see below apiol) essential parsley fruit oil (Oleum Petroselini).
LiteratureThis section has been translated automatically.
- Bridgeman BB et al (2016) Inhibition of mTOR by apigenin in UVB-irradiated keratinocytes: A new implication of skin cancer prevention. Cell Signal 28:460-468.
- Hakobyan A et al (2016) Apigenin inhibits African swine fever virus infection in vitro. Arch Virol 161:3445-3453.
- Hasnat MA et al. (2015) Apigenin Attenuates Melanoma Cellby Inducing Anoikis t hrough Integrin and Focal Adhesion Kinase Inhibition. Molecules 20:21157-21166.
- Meepagala KM et al. (2005)Phytotoxic and antifungal compounds from two Apiaceae species, Lomatium californicum and Ligusticum hultenii, rich sources of Z-ligustilide and apiol, respectively. J Chem Ecol 31:1567-1578.
- Patil RH et al. (2016) Anti-inflammatory effect of apigenin on LPS-induced pro-inflammatory mediators and AP-1 factors in human lung epithelial cells. Inflammation 39:138-147.
- Schilcher H (2016) In: Leitfaden Phytotherapie, Urban & Fischer Verlag Munich, pp. 245 f.
- Song HY et al. (2011) Acaricidal activities of apiol and its derivatives from Petroselinum sativum seeds against Dermatophagoides pteronyssinus, Dermatophagoides farinae, and Tyrophagus putrescentiae. J Agric Food Chem 59:7759-7764.
- Song M et al. (2016) Apigenin protects mice from pneumococcal pneumonia by inhibiting the cytolytic activity of pneumolysin. Fitoterapia 115:31-36.
- Wenigmann M. (2017) Phytotherapy medicinal drugs, phytopharmaceuticals, application. Urban & Fischer, pp. 170-171