Oleanolic acid

Authors: Prof. Dr. med. Peter Altmeyer, Prof. Dr. med. Martina Bacharach-Buhles

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Last updated on: 29.10.2020

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Caryophylline; CAS No: 508-02-1; oleanolic acid (engl.)

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Pentacyclic triterpene (triterpensapogenin) with a carboxyl group, which is almost insoluble in water but highly soluble in methanol.

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Oleanolic acid is contained as a natural substance in a variety of plants so in: sage (Salvia officinalis), taiga root (Eleuterococcus erthraea), common ivy (Hedera helix), sugar beet (Beta vulgaris), ginseng (Panax ginseng), plantain (Plantago major), Syzygium cumini, pistachios (Pistazia vera), olive leaves (Olea europaea) and others.

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Oleanolic acid is weakly cytotoxic, has an antioxidative, antiproliferative potential. Inhibition of TNF-alpha and IL-1beta was experimentally proven. Clinical applications prove successful in the treatment of atopic eczema. Various derivatives of oleanolic acid (e.g. bardoxolone) have a significantly stronger antiproliferative and proapoptotic effect (various derivatives are under clinical investigation).

Field of application/use
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Perorally applied oleanolic acid is used in China and Japan for liver diseases. It is also used for hyperlipidemia and non-lymphatic leukemia.

External: Creams containing oleanol are available on the market for protection against skin cancer. Experimental: Atopic eczema.

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