Authors: Prof. Dr. med. Peter Altmeyer, Prof. Dr. med. Martina Bacharach-Buhles

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Last updated on: 29.10.2020

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Pale yellow plant dye that can be found in numerous plants, such as Achillea millifolium(yarrow), Matricaria recutita(true camomile), Chamaemelum nobile and others. Apigenin is the aglycone of apiin.

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Chemically it is a flavone derivative. Apigenin is the aglucone of apiin. Apigenin acts experimentally cytostatic or antiproliferative (detectable in melanoma cell cultures), antiviral (Hakobyan et al. 2016). A UV-protective effect could be demonstrated in keratinocyte cultures. Furthermore, it is an inhibitor of human oestrogen synthetase. Apiin is the flavone glycoside of apigenin.

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  1. Bridgeman BB et al (2016) Inhibition of mTOR by apigenin in UVB-irradiated keratinocytes: A new implication of skin cancer prevention. Cell signal 28:460-468.
  2. Hakobyan A et al. (2016) Apigenin inhibits African swine fever virus infection in vitro. Arch virol 161:3445-3453.
  3. Hasnat MA et al. (2015) Apigenin Attenuates Melanoma Cellby Inducing Anoikis t hrough Integrin and Focal Adhesion Kinase Inhibition Molecules 20:21157-21166.
  4. Patil RH et al (2016) Anti-Inflammatory Effect of Apigenin on LPS-Induced Pro-Inflammatory Mediators and AP-1 Factors in Human Lung Epithelial Cells. Inflammation 39:138-147.
  5. Song M et al (2016) Apigenin protects mice from pneumococcal pneumonia by inhibiting the cytolytic activity of pneumolysin. Fitoterapia 115:31-36.