Agni cast fructus

Authors: Prof. Dr. med. Peter Altmeyer, Prof. Dr. med. Martina Bacharach-Buhles

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Last updated on: 29.10.2020

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Agni casti fructus; fructus agni casti; Keuschlamfruits; Monk's pepper fruits

Spectrum of action
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Ingredients of Frcutus agni casti: bicyclic diterpenes (e.g. rotundifuran), iridoid glycosides (agnuside, aucubin), lipophilic flavonols, hydrophilic flavones e.g. casticin (see below flavonoids), triglycerides, essential oils (with cineol and pinenes), sesquiterpenes.

Effects: Reduction of basal and stimulated prolactin secretion in cell cultures, dose-dependent antagonisation of haloperidol, binding to the D2-dopamine receptors of lactotropic cells, inhibition of prolactin secretion

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hyperprolactinaemia (E22.1.), premenstrual syndrome (N94.3), mastodynia (N64.5)

Undesirable effects
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allergic reactions with angioedema and urtiacardial exanthema, headache, dizziness, psychosomatic agitation (rare), hallucinations (rare), confusion (rare)

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Agnolyt® solution or capsules, Agno-Sabona® capsules, Agnucaston® film tablets or solution, Biofem® film tablets, Castufemin® solution, Cefanorm® capsules or solution, Femicur N® capsules, Feminon A® capsules, Sarai® capsules.

Dosage: 2 to 4 mg dry extract (see leaflet)

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If a feeling of tension or swelling in the breasts or disturbances in menstrual bleeding should occur, an exact diagnostic clarification is recommended.

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  1. Carmichael AR (2008) Can Vitex Agnus Castus be Used for the Treatment of Mastalgia? What is the Current Evidence? Evid Based Complement Alternat Med 5:247-250.
  2. Halaska M et al (1998) Treatment of cyclical mastodynia using an extract of Vitex agnus castus: results of a double-blind comparison with a placebo. Ceska Gynekol 63:388-392.
  3. Loew D (2012) in Beer A M et al [Ed.] Leitfaden Naturheilverfahren für die ärztliche Praxis, Urban und Fischer Verlag S 185.
  4. Šošić-Jurjević B et al. (2016) Functional morphology of pituitary -thyroid and -adrenocortical axes in middle-aged male rats treated with Vitex agnus castus essential oil. Acta Histochem doi: 10.1016/j.acthis.2016.07.007.
  5. Tamagno G (2009) Are changes of prolactin levels the effectors of vitex agnus castus beneficial effects on the pre-menstrual syndrome? Maturitas 63:369.
  6. Tamagno G et al (2007) Vitex agnus castus might enrich the pharmacological armamentarium for medical treatment of prolactinoma. Eur J Obstet Gynecol Reprod Biol 135:139-140.
  7. YE Q et al (2010) Casticin, a flavonoid isolated from Vitex rotundifolia, inhibits prolactin release in vivo and in vitro. Acta Pharmacol Sin 31:1564-1568.

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Agni casti fructus; Keuschlamfruits;