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DefinitionThis section has been translated automatically.
Witebsky's postulates describe in general terms the prerequisites for autoimmunity.
General informationThis section has been translated automatically.
- Detection of autoantibodies or autoreactive T cells.
- Reproduction of the disease by transfer of autoantibodies/T-cells (e.g. in animal models).
- Induction of the disease by immunization with the autoantigen.
- Improvement after removal or blockade of the autoantibody/T-cells.
Note(s)This section has been translated automatically.
Witebsky's postulates are used in modern immunology to prove autoimmunity causally - a kind of "autoimmunological equivalent" to Koch's postulates in microbiology.
LiteratureThis section has been translated automatically.
- Koneczny I (2018) A New Classification System for IgG4 Autoantibodies. Front Immunol 9:97.
