Cytostatic drug, vinca alkaloid (see also vinblastine), which is semi-synthetically extracted from vinca rosea of an evergreen species. Vincristine binds specifically to beta-tubulin and thus blocks the polymerisation with alpha-tubulin to form microtubules.
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Vincrist
DefinitionThis section has been translated automatically.
Half-lifeThis section has been translated automatically.
85 hours.
IndicationThis section has been translated automatically.
Leukaemia, Hodgkin's disease (see lymphogranulomatosis, malignant), non-Hodgkin's lymphomas, metastatic malignant melanoma, AIDS-associated Kaposi's sarcoma, bronchial carcinoma.
Pregnancy/nursing periodThis section has been translated automatically.
Contraindicated during pregnancy (in animal experiments embryo- or fetotoxic). Contraindicated during lactation (it is not known whether the substance passes into breast milk).
Dosage and method of useThis section has been translated automatically.
1.4 mg/m2 KO i.v. once a week.
Undesirable effectsThis section has been translated automatically.
BB changes, gastrointestinal disorders, subileus, liver or kidney damage, hyperuricemia, alopecia (see alopecia medicamentosa), dermatitis, stomatitis, erythroderma, neurotoxic disorders, disorders of spermiogenesis and ovulation.
PreparationsThis section has been translated automatically.
Vincristine sulphate Hexal, vincristine Bristol
LiteratureThis section has been translated automatically.
- Aldenhoven M et al (2006) Therapeutic strategies for epidemic Kaposi's sarcoma. Int J STD AIDS 17: 571-578