Cytostatic drug, vinca alkaloid which is semi-synthetically extracted like vincristine from vinca rosea, an evergreen species.
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Vinblastine
DefinitionThis section has been translated automatically.
Half-lifeThis section has been translated automatically.
25 h
Pharmacodynamics (Effect)This section has been translated automatically.
Inhibition of intracellular tubulin synthesis. Arrest of the cells in the metaphase of mitosis. Disruption of DNA and RNA synthesis. Induction of apoptosis.
IndicationThis section has been translated automatically.
M. Hodgkin, mycosis fungoides, testicular carcinoma, malignant melanoma, Kaposi's sarcoma.
Notice! During the therapy and up to 6 months afterwards, effective contraception must be carried out.
Dosage and method of useThis section has been translated automatically.
3.7 mg/m2 KO/day i.v. every 1-2 weeks or in polychemotherapy 6-8 mg/m2 KO/day for 1-2 days every 3-4 weeks.
Undesirable effectsThis section has been translated automatically.
BB changes, gastrointestinal disorders, subileus, liver or kidney damage, hyperuricemia, alopecia (see alopecia medicamentosa), dermatitis, stomatitis, erythroderma, neurotoxic disorders, disorders of spermiogenesis and ovulation. Very rarely dyspnoea or respiratory disorders.
InteractionsThis section has been translated automatically.
The administration of myelotoxic substances increases bone marrow toxicity and the blood sugar-lowering effect of oral antidiabetics is enhanced.
ContraindicationThis section has been translated automatically.
Pregnancy, lactation, acute infections, severe bone marrow depression.
PreparationsThis section has been translated automatically.
Vinblastine 10 Hexal