DefinitionThis section has been translated automatically.
Test procedure to check the TSH secretion reserve in borderline thyroid dysfunction such as preclinical hypo- or hyperthyroidism. Note: due to the high quality TSH assays this test is usually unnecessary.
IndicationThis section has been translated automatically.
Further indications:
Detection of secretion rigidity in TSH-producing tumours.
Detection of thyroid hormone resistance (excessive stimulation)
Contraindication: Known hypersensitivity to TRH; spasms, severe obstructive bronchial diseases, unstable angina pectoris, fresh myocardial infarction
ImplementationThis section has been translated automatically.
In the TRH test, the basal TSH value in the blood is measured first. Then 200 µg thyrooliberine is slowly injected intravenously. After 30 minutes another blood sample is taken to determine the TSH value again.
Reference values for the laboratory value TRH:
- TSH increase: > 2.5 times the base value
- TSH maximum: < 25 mU/ml
Absence or reduction of increase: hyperthyroidism, autonomy, secondary (pituitary) hypothyroidism, suppression of hypothalamic function by SD thyroid medication
Excessive increase: subclinical hypothyroidism, primary hypothyroidism, SD hormone resistance
LiteratureThis section has been translated automatically.
Böhm O (2018) Thyroid hormones. In: Neumeister B et al (Eds) Clinical guide to laboratory diagnostics. Elsevier GmbH S. 299-300
Prof. Dr. med. Peter Altmeyer