OSMR gene

The OSMR gene (OSMR stands for Oncostatin M Receptor) is a protein-coding gene located on chromosome 5p13.1. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

The OSMR gene Gene encodes a member of the type I cytokine receptor family. The encoded protein heterodimerizes with the interleukin-6 signal transducer to the type II oncostatin M recept or and with the interleukin-31 receptor A to the interleukin-31 receptor, thus transmitting oncostatin M- and interleukin-31-induced signaling events.

Mutations in this gene have been associated with familial primary localized cutaneous amyloidosis.

Biological processes associated with this gene include growth factor binding and oncostatin M receptor activity.

1. Schreml S et al (2013) Familial primary localized cutaneous amyloidosis with an oncostatin M receptor-β mutation, Pro694Leu. Clin Exp Dermatol 38:932-935.
2. Suranagi VV et al (2015) Bullous variant of familial biphasic lichen amyloidosis: a unique combination of three rare presentations. Indian J Dermatol 60:105
3. Wang WH et al (2012) A new c.1845A→T of oncostatin M receptor-β mutation and slightly enhanced oncostatin M receptor-β expression in a Chinese family with primary localized cutaneous amyloidosis. Eur J Dermatol 22:29-33.
4. Wali A et al (2015) Familial primary localized cutaneous amyloidosis results from either dominant or recessive mutations in OSMR. Acta Derm Venereol 95:1005-1007.