HistoryThis section has been translated automatically.
Fuchs 1896; Laffer 1909; Ascher 1920;
DefinitionThis section has been translated automatically.
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EtiopathogenesisThis section has been translated automatically.
Unknown; possibly dominant gene (father-daughter observation). Mutation not yet detected. Pathogenetically, after recurrent oedemas the upper eyelid skin sagging and atrophy, hyperplasia of prolapsed orbital fat, double lip as manifestation of post-edematous vascular and connective tissue proliferation.
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Clinical featuresThis section has been translated automatically.
After the 5th year of life repeated occurrence of painless swelling of the upper eyelids and upper lips, on the upper lids the recurrent swelling is followed by doughy soft upper eyelid bags, formed by slack, atrophic skin. Blood vessels shimmer bluishly through the skin. In the affected children the swelling of the upper eyelids and upper lip is often misinterpreted as angioedema. Only blepharochalasis caused by prolapsed orbital fat and tear gland tissue consolidates the diagnosis. The duplication of the lips (double lip) continues to point the way forward; usually the upper lip is affected, rarely the lower lip.
Euthyroid goiter possible after puberty. In the full picture combination of blepharochalasis, double lip, goiter and endocrine disorders. Edematous lip swelling and blepharochalasis are initially reversible and finally persistent due to fibrous transformation.
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LiteratureThis section has been translated automatically.
- Ashtray KW (1920) Blepharochalasis with goiter and double lip. Klin Monatsbl Ophthalmology (Stuttgart) 65: 86-97
- Fuchs E (1896) On blepharochalasis (flaccidity of the eyelid skin). Wiener klin Weekly 9: 109
- Gomez-Duaso AJ et al (1997) Ascher syndrome: report of two cases. J Oral Maxillofac Surgery 55: 88-90
- Hausamen JE, Solbach HG, Pape HD (1969) Clinical contribution to Ascher syndrome. German dentist Z 24: 983-987
- Kara IG et al (2001) Ascher syndrome. Otolaryngol Head Neck Surgery 124: 236-237
- Laffer WB (1909) Blepharochalasis. Report of a case of this trophoneurosis, involving also the upper lip. Cleveland Med J 8: 131-135
- Parmar RC et al (2004) A newly recognized syndrome with double upper and lower lip, hypertelorism, eyelid ptosis, blepharophimosis, and third finger clinodactyly. Am J Med Genet 124A: 200-201
Incoming links (4)Blepharochalasis; Double lip; Facial swelling; Macrochilelia;
Outgoing links (3)Cheilitis granulomatosa; Double lip; Melkersson-rosenthal syndrome;
Please ask your physician for a reliable diagnosis. This website is only meant as a reference.