DefinitionThis section has been translated automatically.
LENG8 (Leukocyte Receptor Cluster Member 8) is a protein-coding gene located on chromosome 19q13.42. An important paralog of this gene is MCM3AP.
General informationThis section has been translated automatically.
The encoded protein is probably part of a proteinaceous complex that is active in the nucleus.
Diseases associated with LENG8 include combined oxidative phosphorylation deficiency 8 and immunodeficiency, often variable, 1.
SNPs in LENG8 have been detected in endemic pemphigus foliaceus (Farias TDJ et al. 2019).
LiteratureThis section has been translated automatically.
- Calonga-Solís V et al. (2021) Variation in genes implicated in B-cell development and antibody production affects susceptibility to pemphigus. Immunology 162:58-67
- Li N et al. (2022) From Insect Bites to a Skin Autoimmune Disease: A Conceivable Pathway to Endemic Pemphigus Foliaceus. Front Immunol 13:907424.
- Farias TDJ et al. (2019) Screening the full leucocyte receptor complex genomic region revealed associations with pemphigus that might be explained by gene regulation. Immunology 156:86-93.
