The first determination of total protein in urine was achieved by Cotugno (1736 - 1822) in 1797 by precipitation with nitric acid. He called the detected protein: "albam massam tenerrimo iam coacto ovi albumine persimilem" (dense white substance like the white of a boiled egg). From this, the term "albumin" was later derived (Gressner 2013; Hofmann 2001).
Teissier was the first to describe orthostatic proteinuria in 1899 (Kluthe 2013).