Eosinophilia D72.1

Last updated on: 26.10.2021

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Eosinophilia is defined as an elevated eosinophil concentration in the peripheral blood.

  • Eosinophil counts of > 500/μl correspond to a weak eosinophilia.
  • Eosinophil counts of 1500/μl correspond to moderate eosinophilia
  • Eosinophil counts of > 5000/μl correspond to severe eosinophilia.

The causes are heterogeneous and require differentiation between a:

  • primary eosinophilia due to a haematological neoplasm, e.g. eosinophil leukaemia (CEL)
  • a secondary eosinophilia
  • a reactive eosinophilia, e.g. caused by parasitic infestation or allergic reactions
  • an ideopathic eosinophilia(hypereosinophilia syndrome - HES).

In the case of eosinophil leukemia (chronic eosinophil leukemia- CEL-NOS), the persistent eosinophilia is due to clonal proliferation of an eosinophil precursor.

Within the WHO major category, CEL-NOS is classified in the myeloproliferative neoplasia (MPN) group and can be diagnosed by an eosinophil concentration > 1500/μl, evidence of clonal cytogenetic or molecular genetic markers, and exclusion of the following criteria:

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This section has been translated automatically.

  1. Wozel G (2007) Eosinophilia dermatoses. Dermatologist 58: 347-360


Please ask your physician for a reliable diagnosis. This website is only meant as a reference.

Last updated on: 26.10.2021