CXCR5 Gene

CXCR5 (C-X-C Motif Chemokine Receptor 5) is a protein-coding gene located on chromosome 11q23.3. The CXCR5 gene encodes a membrane protein that belongs to the CXC chemokine receptor family. The chemokine receptor is expressed in mature B cells and in Burkitt's lymphoma. It binds to the B lymphocyte chemoattractant (BLC) and is involved in the migration of B cells to the B cell follicles of the spleen and Peyer's plaques, but not to those of the mesenteric or peripheral lymph nodes. May have a regulatory function in Burkitt's lymphoma (BL) lymphomagenesis and/or B-cell differentiation.

Several alternatively spliced transcript variants encoding different isoforms have been described for this gene. Diseases associated with CXCR5 include intraocular lymphoma and lymphoma.

1. Chen Yet al. (2019) CXCR5+PD-1+ follicular helper CD8 T cells control B cell tolerance. Nat Commun 10: 4415.
2. Li H et al. (2015) CD25(+) Bcl6(low) T follicular helper cells provide help to maturing B cells in germinal centers of human tonsil. Eur J Immunol 45: 298-308.
3. Vinuesa CG et al (2016) Follicular Helper T Cells. Annu Rev Immunol 34:335-368.