Cholangitis primary sclerosing K83.0

Author: Prof. Dr. med. Peter Altmeyer

All authors of this article

Last updated on: 29.10.2020

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Synonym(s)

PSC

Definition
This section has been translated automatically.

Sclerosing chronic inflammation of the extra- and intrahepatic bile ducts with consecutive destruction of the bile ducts.

Occurrence/Epidemiology
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Prevalence 1:100,000 per year

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Etiopathogenesis
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Unresolved

Manifestation
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Increased occurrence between the 30-50 LJ;

Clinic
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In the early stages asymptomatic. Later unclear upper stage symptoms, weight loss, icterus, itching.

The disease is more often than not accompanied by "chronic inflammatory bowel disease" (CED), usually ulcerative colitis. Furthermore, an association with the Sjögren's syndrome is found.

Laboratory
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Increased cholestasis parameters; frequent (60%) detection of ANA and ANCA (p-ANCA).

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Incoming links (2)

CLDN1 Gene; Neonatal-ithyosis-sclerosing-cholangitis-syndrome;

Outgoing links (3)

Anca; Antinuclear antibodies; Sjögren's syndrome;

Disclaimer

Please ask your physician for a reliable diagnosis. This website is only meant as a reference.

Authors

Last updated on: 29.10.2020

Author: Prof. Dr. med. Peter Altmeyer Prof. Dr. med. Peter Altmeyer

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