Anca $$$

Author: Prof. Dr. med. Peter Altmeyer

All authors of this article

Last updated on: 29.10.2020

Dieser Artikel auf Deutsch

Synonym(s)

Antineutrophil cytoplasmatic antibodies"; Anti-Neutrophil Cytoplasmic Antibodies; Antineutrophilic cytoplasmic antibodies; Cytoplasmic antibodies antineutrophilic

Definition
This section has been translated automatically.

ANCA is an acronym for "antineutrophil cytoplasmatic antibodies", a collective term for cytoplasmic(lysosomal) antigens in neutrophil granulocytes. Cytoplasmatic antigens (cANCA) and perinuclear antigens (pANCA; e.g. myeloperoxidase) are distinguished on the basis of the fluorescence pattern and localisation within the cell.

General information
This section has been translated automatically.

According to the pattern produced by indirect immunofluorescence on human leukocytes can be divided as follows:

Standard value: The reference range is not detectable

Pathologically increased: Crohn's disease and ulcerative colitis, rheumatoid arthritis, systemic lupus, Churg-Strauss syndrome, microscopic panarteritis, Wegener's granulomatosis, vasculitis of medium and large vessels.

Implementation
This section has been translated automatically.

Test material: Serum.

Determination method:

  • Indirect IFT: on ethanol-fixed granulocytes
  • ELISA with purified antigen: cANCA →neutrale Proteinase 3 (PR3-ANCA); pANCA → Myeloperoxidase

Note(s)
This section has been translated automatically.

The cANCA have a pathogenetic significance in that, after binding of the antibody to granulocytes, they induce a cascade of immunological processes which finally lead to cytokine release, endothelial activation and lymphocytic infiltration of the small vessels with consecutive vasculitis.

Authors

Last updated on: 29.10.2020