DefinitionThis section has been translated automatically.
AST refers to an enzyme (Herold 2022) that catalyzes a reversible transamination between L- aspartate and 2- oxoglutarate to oxaloacetate and L- glutamate (Gressner 2012).
ClassificationThis section has been translated automatically.
General informationThis section has been translated automatically.
It is an enzyme found in a variety of organs including liver, kidney, pancreas, lung, brain, erythrocytes, leukocytes, and cardiac and skeletal muscle, but is not liver specific (Herold 2022).
Within the liver, 80% of AST is found in mitochondria and 20% in cytoplasm (Halwachs- Baumann 2011).
The AST- normal value is < 31 U / l for women and < 35 U / l for men (Lohmann 2020).
AST is primarily used for the early detection of liver and biliary diseases (Lohmann 2020).
An increase in AST can occur due to:
- cirrhosis of the liver
- Diseases of the bile ducts
- Diseases of the pancreas
- alcohol or drug consumption (Lohmann 2020)
- physical stress
In a marathon runner, for example, a 2-3 fold increase in AST has been described (Kindermann 2007).
- muscle trauma
- myocardial infarction (Herold 2022)
LiteratureThis section has been translated automatically.
- Gressner A M, Arndt T (2012) Lexikon der Medizinischen Laboratoriumsdiagnosti. Volume 1 - clinical chemistry. Springer Verlag Germany / New York 133
- Herold G et al (2022) Internal medicine. Herold Publishers 516
- Kasper D L, Fauci A S, Hauser S L, Longo D L, Jameson J L, Loscalzo J et al (2015) Harrison's Principles of Internal Medicine. Mc Graw Hill Education
- Kindermann W, Dickhuth H H, Nieß A, Röcker K, Urhausen A (2007) Sports cardiology: physical activity in heart disease. Steinkopff Verlag Darmstatdt 121
- Lohmann M (2020) Understanding laboratory values: blood, urine and stool analyses, normal values at a glance, technical terms and important abbreviations. Mankau- Verlag Murnau Chapter: Physical disorders and organ diseases.