Aseptic abscesses syndrome K50.-

Last updated on: 22.09.2022

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Systemic disease of unclear etiology associated with inflammatory bowel disease (e.g., Crohn's disease), intra-abdominal aseptic abscesses, fever, abdominal pain, and leukocytosis.

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In a larger collective, the mean age in patients with "aseptic abscess syndrome" was 29 years (SD = 14).

Clinical features
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Inflammatory bowel disease (IBD) may precede abscess formation, occur concurrently with it, or manifest later. The main clinical manifestations of AA are fever (90%), abdominal pain (67%), weight loss (50%). The abscess formations involve the spleen in > 90% (Fillman H et al 2020). They can occur unifocally but also multifocally, with additional involvement of the abdominal lymph nodes in about 50% of patients, the liver in about 40%, the lungs in 17%, the pancreas in 7%, and the brain in 7%.


  • About 20% of patients had neutrophilic dermatosis (20%).
  • 10% suffered from recurrent polychondritis.
  • An association with Sweet syndrome (Sutton E et al. 2018) and systemic lupus erythematosus (Andonopoulos AP et al. 1986) was occasionally reported.

Other symptoms: monoclonal gammopathy of undetermined significance(MGUS).

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Neutrophilia; detection of antineutrophil cytoplasmic autoantibodies with perinuclear, cytoplasmic, or atypical pattern (negative for antiproteinase 3 and negative for antimyeloperoxidase.

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  1. Agirgol S et al (2020) Aseptic Abscess Syndrome with Severe Skin Involvement: Case Report. Indian J Dermatol 65:434-436.
  2. André MFJ et al (2007) Aseptic abscesses: a study of 30 patients with or without inflammatory bowel disease and review of the literature. Medicine (Baltimore) 86:145-161.
  3. Andonopoulos AP et al (1986) Successfully treated splenic abscess in a systemic lupus erythematosus patient. A case report and review of the literature. Clin Exp Rheumatol 4: 269-271.
  4. Bollegala N et al. (2017) Aseptic abscesses and inflammatory bowel disease: two cases and review of literature. Can J Gastroenterol Hepatol 2017:5124354.
  5. Fillman H et al (2020) Aseptic abscess syndrome. BMJ Case Rep13(10):e236437.
  6. Sutton E et al (2018) Sweet syndrome with aseptic splenic abscesses and multiple myeloma. Cutis 101: E27-E29.


Please ask your physician for a reliable diagnosis. This website is only meant as a reference.

Last updated on: 22.09.2022