DefinitionThis section has been translated automatically.
Systemic disease of unclear etiology associated with inflammatory bowel disease (e.g., Crohn's disease), intra-abdominal aseptic abscesses, fever, abdominal pain, and leukocytosis.
ManifestationThis section has been translated automatically.
In a larger collective, the mean age in patients with "aseptic abscess syndrome" was 29 years (SD = 14).
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Clinical featuresThis section has been translated automatically.
Inflammatory bowel disease (IBD) may precede abscess formation, occur concurrently with it, or manifest later. The main clinical manifestations of AA are fever (90%), abdominal pain (67%), weight loss (50%). The abscess formations involve the spleen in > 90% (Fillman H et al 2020). They can occur unifocally but also multifocally, with additional involvement of the abdominal lymph nodes in about 50% of patients, the liver in about 40%, the lungs in 17%, the pancreas in 7%, and the brain in 7%.
- About 20% of patients had neutrophilic dermatosis (20%).
- 10% suffered from recurrent polychondritis.
- An association with Sweet syndrome (Sutton E et al. 2018) and systemic lupus erythematosus (Andonopoulos AP et al. 1986) was occasionally reported.
Other symptoms: monoclonal gammopathy of undetermined significance(MGUS).
LaboratoryThis section has been translated automatically.
Neutrophilia; detection of antineutrophil cytoplasmic autoantibodies with perinuclear, cytoplasmic, or atypical pattern (negative for antiproteinase 3 and negative for antimyeloperoxidase.
LiteratureThis section has been translated automatically.
- Agirgol S et al (2020) Aseptic Abscess Syndrome with Severe Skin Involvement: Case Report. Indian J Dermatol 65:434-436.
- André MFJ et al (2007) Aseptic abscesses: a study of 30 patients with or without inflammatory bowel disease and review of the literature. Medicine (Baltimore) 86:145-161.
- Andonopoulos AP et al (1986) Successfully treated splenic abscess in a systemic lupus erythematosus patient. A case report and review of the literature. Clin Exp Rheumatol 4: 269-271.
- Bollegala N et al. (2017) Aseptic abscesses and inflammatory bowel disease: two cases and review of literature. Can J Gastroenterol Hepatol 2017:5124354.
- Fillman H et al (2020) Aseptic abscess syndrome. BMJ Case Rep13(10):e236437.
- Sutton E et al (2018) Sweet syndrome with aseptic splenic abscesses and multiple myeloma. Cutis 101: E27-E29.
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