Angiotensinogen

Author: Prof. Dr. med. Peter Altmeyer

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Last updated on: 29.10.2020

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History
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Ohkubo et al. 1983

Definition
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Angiotensinogen is a protein, a prohormone with 452 amino acids with a molecular weight of 49,761 Da. The coding gene is located on the long arm of chromosome 1 (Chr 1: 228.9 - 228.92 ). After translation by hepatocytes and transport to the liver cell membrane, the peptide angiotensin I , which consists of 10 amino acids, is cleaved off, the actual effective signal sequence. The resulting angiotensinogen is released into the plasma.

General information
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The angiotensinogen formed in the liver circulates in human blood plasma. During the electrophoretic separation of serum proteins, it migrates in the α2 globulin fraction.

Incoming links (1)

Aliskiren;

Outgoing links (1)

Angiotensin i;

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Last updated on: 29.10.2020