Akt1 Gene

Author: Prof. Dr. med. Peter Altmeyer

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Last updated on: 05.11.2021

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ACT Serine/Threonine Kinase 1; OMIM:164730; PKB; PKB alpha; Protein Kin1ase B; Protein Kinase B Alpha; Proto-Oncogene C-Act; RAC; RAC alpha serine/threonine protein kinase; RAC-PK-Alpha; V-Act Murine Thymoma Viral Oncogene Homolog 1

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AKT1 (AKT Serine / Threonine Kinase 1) is a gene located on chromosome 14q32.33 that encodes AKT serine-threonine protein kinase 1. Originally, AKT1 was identified as an oncogene in the transforming retrovirus AKT8.

The AKT1 protein is one of 3 closely related serine/threonine protein k inases (AKT1 kinae, AKT2 kinaeand AKT3 kinase) collectively referred to as AKT serine-threonine kinases. AKT serine-threonine kinases regulate many processes, including metabolism, proliferation, cell survival, growth, and angiogenesis. Thus, AKT1 is an important mediator of growth factor-induced neuronal survival. Furthermore, serine / threonine protein kinases appear to play a significant role in mediating growth signaling. AKT1 and the related AKT2 are activated by phosphatidylinositol 3-kinase, a platelet-induced growth factor.

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Diseases associated with mutations in AKT1 include Proteus syndrome and Cowden syndrome.


Last updated on: 05.11.2021