Akt1 gene

Author: Prof. Dr. med. Peter Altmeyer

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Last updated on: 29.10.2020

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ACT Serine/Threonine Kinase 1; OMIM:164730; PKB; PKB alpha; Protein Kin1ase B; Protein Kinase B Alpha; Proto-Oncogene C-Act; RAC; RAC alpha serine/threonine protein kinase; RAC-PK-Alpha; V-Act Murine Thymoma Viral Oncogene Homolog 1

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AKT1 (AKT Serine / Threonine Kinase 1) is a gene located on chromosome 14q32.33 and encodes the serine threonine protein kinase. Originally, AKT1 was identified as an oncogene in the transforming retrovirus AKT8.

The AKT1 protein is one of 3 closely related serine / threonine protein kinases (AKT1, AKT2 and AKT3), which together are referred to as AKT kinases. AKT kinases regulate many processes including metabolism, proliferation, cell survival, growth and angiogenesis. Thus, AKT1 is an important mediator of growth factor-induced neuronal survival. Furthermore, the serine / threonine protein kinases appear to play an important role in the mediation of growth signals. AKT1 and related AKT2 are activated by phosphatidylinositol-3-kinase, a platelet-induced growth factor.

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Diseases associated with mutations in AKT1 include Proteus syndrome and Cowden syndrome.

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Proteus syndrome;


Last updated on: 29.10.2020