Zieve syndrome K70.0

Author: Prof. Dr. med. Peter Altmeyer

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Last updated on: 22.01.2024

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History
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Zieve, 1958

Definition
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Alcohol-induced icterus with pancreatitis, hyperlipidemia (triglycerides and cholesterol) and hemolytic anemia.

Etiopathogenesis
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Occurs with chronic alcohol consumption and consecutive liver insufficiency.

Bilirubin binds to elastin with increased affinity; jaundice manifests itself first in the sclera (increased elastin content).

Clinical features
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Jaundice of varying severity.

Hardly any skin changes in the hemolytic phase.

As the disease progresses, non-itching (almost asymptomatic), scaly, centrifugally growing, circulatory erythema (probably identical to erythema necroticans migrans).

Therapy
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Therapy of the underlying disease, regression of the skin change in case of prolonged alcohol withdrawal!

Literature
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  1. Vogl A et al (2005) Skin and alcohol. J Dtsch Dermatol Ges 3: 788-790
  2. Zieve L (1958) Jaundice, hyperlipemia and hemolytic anemia: a heretofore unrecognized syndrome associated with alcoholic fatty liver and cirrhosis. Ann Intern Med 48: 471-496

Outgoing links (1)

Erythema necrolyticum migrans;

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Please ask your physician for a reliable diagnosis. This website is only meant as a reference.

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Last updated on: 22.01.2024