Tropisetron

Author: Prof. Dr. med. Peter Altmeyer

All authors of this article

Last updated on: 20.05.2022

Dieser Artikel auf Deutsch

Definition
This section has been translated automatically.

5-HT3 antagonist, antiemetic.

Pharmacodynamics (Effect)
This section has been translated automatically.

Selective, competitive binding to 5-HT3 receptors in the brain, among other places. As a result, serotonin can no longer bind to its binding sites, the 5-HT3 receptors, and exert its effect. This directly prevents the development of nausea and vomiting, among other things.

Indication
This section has been translated automatically.

Prophylaxis of cytostatic-induced nausea and vomiting.

Limited indication
This section has been translated automatically.

Pregnancy, lactation, children < 2 years, hypertension, cirrhosis of the liver, renal failure.

Pregnancy/nursing period
This section has been translated automatically.

Do not use during pregnancy or lactation (insufficient data available; it is not known whether the active ingredient passes into breast milk).

Dosage and method of use
This section has been translated automatically.

5 mg slowly i.v. or as a short infusion immediately before chemotherapy, afterwards up to 5 days 5 mg/day p.o. For peroral therapy 0.2 ml injection solution/kg bw (= 0.2 mg/kg bw) up to max. 5 ml (1 amp. 5 mg/ml) can be mixed with orange juice or cola and drunk. For the intake of 5 mg/day 1 Kps. p.o. can also be taken.

Undesirable effects
This section has been translated automatically.

  • Cutaneous ADRs: Occasional allergic or anaphylactic reactions. Slight exanthematic skin changes and oedema, especially facial oedema. Local reactions at the infusion site.
  • Extracutaneous ADRs: headache, dizziness, hypertension, lymphadenopathy, gastrointestinal disorders (constipation or diarrhea), arthralgia.

Interactions
This section has been translated automatically.

Phenobarbital, phenytoin and rifampicin lead to a reduction of the tropisetron level.

Contraindication
This section has been translated automatically.

Use in children, hypersensitivity reactions to other 5-HT3 antagonists.

Preparations
This section has been translated automatically.

Navoban

Outgoing links (3)

Antiemetics; Phenytoin; Rifampicin;

Authors

Last updated on: 20.05.2022