Trimethoprim

Author: Prof. Dr. med. Peter Altmeyer

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Last updated on: 29.10.2020

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Definition
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Half-life
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10, 11 hours.

Pharmacodynamics (Effect)
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Inhibition of folic acid biosynthesis by inhibition of dihydrofolic acid reductase.

Spectrum of action
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Gram positive and negative aerobic bacteria, Plasmodium spp. and Pneumocystis carinii.

Indication
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Infections with gram-negative germs, malaria, Pneumocystis carinii pneumonia.

Dosage and method of use
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  • Adults/young people > 12 years: 2 times/day 150-200 mg p.o.
  • Children < 12 y. 2 times/day 3 mg/kg bw p.o.
  • Pneumocystis carinii pneumonia: 4-5 mg/kg bw/6 hours in combination with sulfamethoxazole 20-25 mg/kg bw/6 hours over 2-3 weeks.

Notice! For long-term therapy: megaloblast anaemia (can be compensated by the administration of folic acid).

Undesirable effects
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  • Cutaneous reactions up to toxic epidermal necrolysis, angioedema, fixed drug reactions.
  • Extracutaneous: nausea, vomiting, diarrhoea, BB changes.

Interactions
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Increase of the phenytoin level.

Contraindication
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Pregnancy, nursing.

Preparations
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Infectotrimet, TMP-ratiopharm

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Last updated on: 29.10.2020