Tazobactam/piperacillin
Synonym(s)
piperacillin/tazobactam
Definition
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Half-life
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1 h
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Spectrum of action
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S.u. piperacillin, especially strains of bacteria containing β-lactamase.
Indication
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Infections by piperacillin-sensitive and resistant pathogens, if the resistance is based on the formation of β lactamases
Dosage and method of use
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9-13.5 g/day i.v. in 2-3 ED.
Undesirable effects
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Occasionally: Candida superinfection, leuko-, neutro-, thrombocytopenia.
Interactions
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Increase of neuromuscular blockade of muscle relaxants, increased bleeding tendency when using acetylsalicylic acid, s.a. benzylpenicillin.
Contraindication
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Penicillin allergy, infectious mononucleosis and other viral infections (increased risk of exanthema!), leukemia, pregnancy, lactation, children < 12 years.
Preparations
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Tazobac
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Prof. Dr. med. Peter Altmeyer