T-cell pseudolymphoma cd30 positive L98.8

Author: Prof. Dr. med. Peter Altmeyer

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Last updated on: 29.10.2020

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Definition
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Group of reactive T-lymphocytic tissue reactions that cannot be assigned to a distinct clinical picture. In this respect, this histological terminology is not easily transferred to clinical nomenclature. The causes are often infectious triggers such as insect bite reactions, scabies granuloma, herpes infections; furthermore, these tissue reactions are also detected in pseudolymphoma-like drug reactions.

Histology
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Mostly dense lymphoid cell infiltrate penetrating the dermis, which may also be wedge-shaped; interspersed with esoinophilic granulocytes. In addition, large activated CD30+ lymphocytes, occurring individually or in groups. The histological picture corresponds to lymphomatoid papulosis, which must be clinically defined.

Literature
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  1. Yazdi A, CA Sander (2016) Pseudolymphomas. In: Cerroni L et al. histopathology of the skin. Springer-Verlag Berlin Heidelberg New-York p.899-900
  2. Inoue A et al (2016) CD30-positive Cutaneous Pseudolymphoma Caused by Tocilizumab in a Patient with Rheumatoid Arthritis: Case Report and Literature Review. Acta Derm
  3. Venereol 96: 570-571. Murphy M (2009). Intradermal CD30-positive mononuclear cells in superficial fungal infections of the skin. Mycoses 52:182-186.
  4. Nathan DL et al (1998) Carbamazepine-induced pseudolymphoma with CD-30 positive cells. J Am Acad Dermatol 38: 806-809.
  5. Werner B et al (2008) Large CD30-positive cells in benign, atypical lymphoid infiltrates of the skin. J Cutan Pathol 35: 1100-1107.

Outgoing links (1)

Lymphomatoids papulose;

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Last updated on: 29.10.2020