Syringometaplasia

Histological term describing a mature metaplasia of the eccrine ducts. Eccrine squamous syringometaplasia is not a rare histological finding and may be associated with chemotherapy or a variety of non-specific diseases such as infections, neoplastic diseases and inflammatory skin diseases (e.g. scleromyxedema). The changes are mainly observed in the context of chemotherapy.

Various subtypes of syringometaplasia have been described:

• the squamous type
• the mucinous type
• the adenomatous type

1. Bittar PG et al. (2018) Chemotherapy-induced eccrine squamous syringometaplasia in an infant. Pediatr Dermatol 35:e84-e85.
2. Matei MC et al. (2022) Eccrine squamous syringometaplasia associated with Natalizumab. Dermatol Ther 35:e15576.
3. Velik C et al. (2022) Sorafenib-induced eccrine squamous syringometaplasia. Australas J Dermatol 63:e189-e190