Syringom (overview) D23.L4

Author: Prof. Dr. med. Peter Altmeyer

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Last updated on: 17.07.2021

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Clear cell syringoma

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Rare, benign tumor of the eccrine sweat gland excretory ducts. Syringoma may occur as solitary growths of the skin ubiqitär (not palms and soles). However, this form of syringoma is rather rare.

More common are small "milia-like" syringomas as disseminated syringomas in the eyelid area (lid syringomas).

In a single case, epidermal scrotal cysts (epidermal inclusion cysts) and syringomas were reported to occur together (Diep M et al. 2020).

S.a.u. Hidradenoma.

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By far the most common localization is the lower eyelids (Lidsyringoma). More rarely, the forehead, neck, neck, axillae and abdomen are affected. The genital region (vulva or penis) is very rarely affected.

Clinical features
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Mostly occurring in majority, skin-coloured, 1-3 mm large, flat, firm, completely symptom-free papules. Disseminated syringomas are mainly found on the trunk. Also one-sided naevoidal occurrence arranged in the Blaschko lines is possible.

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  • Dermal tumor formations with numerous roundish to tubular, solid or cystic structures bordered by double-row epithelium, which may contain homogeneous, PAS-reactive material when expanded cystically. Dense fibrous stroma. The clear cell syringoma shows large epithelial cells with bright PAS-positive cytoplasm.
  • Electron microscopy: ductal cells with numerous short microvilli, desmosomes, luminal tonofilaments and lysosomes.

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  1. Frazier CC (2001) The treatment of eruptive syringomas in an African American patient with a combination of trichloroacetic acid and CO2 laser destruction. Dermatol Surgery 27: 489-492
  2. Huang YH (2003) Vulvar syringoma: a clinicopathologic and immunohistologic study of 18 patients and results of treatment. J Am Acad Dermatol 48: 735-739
  3. Mentzel T (2003) Cutaneous myoepithelial neoplasms: clinicopathologic and immunohistochemical study of 20 cases suggesting a continuous spectrum ranging from benign mixed tumor of the skin to cutaneous myoepithelioma and myoepithelial carcinoma. J Cutan Pathol 30: 294-302
  4. Metze D (2001) Familial syringoma: a rare clinical variant. dermatologist 52: 1045-1048
  5. Nguyen DB (2003) Syringoma of the moustache area. J Am Acad Dermatol 49: 337-339
  6. Panizzon R et al (1987) The syringoma of the vulva. Dermatologist 38: 607-609
  7. Park HR et al (2003) Expression of S100A2 and S100B proteins in epithelial tumors of the skin. J Cutan cathode 30: 373-378
  8. Patrizi A et al (1998) Syringoma: A review of twenty-nine cases. Acta Derm Venereol 78: 460-462
  9. Soler-Carrillo J (2001) Eruptive syringoma: 27 new cases and review of the literature. J Eur Acad Dermatol Venereol 15: 242-246
  10. Sungur N (2003) An unusual chondroid syringoma. Dermatol Surge 29: 977-979
  11. Timpanidis PC (2003) Progesterone receptor-positive eruptive syringoma associated with diabetes. J Am Acad Dermatol 48: S103-104


Please ask your physician for a reliable diagnosis. This website is only meant as a reference.


Last updated on: 17.07.2021