Mixed tumour of the skin D23.L

Author: Prof. Dr. med. Peter Altmeyer

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Last updated on: 29.10.2020

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Chondroid hidradenoma; chondroid syringoma; Hidradenoma chondroides; Mixed tumor of the skin; syringoma chondroides

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Hirsch and Helwig, 1961 (Chondroides Syringom)

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Rare adnexal tumor of the skin with apocrine differentiation, which consists of an epithelial and a mesenchymal component. These are tumors of the sweat glands. The term mixed skin tumor appears to be more correct than the term "chondroid syringoma" which is still used in the majority of the literature, as syringoma is reserved for eccrine differentiated adnexal tumors.

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Especially in the area of the hairy head, the neck, centrofacial (nose). Rarely subungual with intrabony spreading or in the area of the scrotum.

Clinical features
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Rough, intra- or subcutaneous, skin-coloured knots, 0.5-3 cm in diameter, which can be moved easily against the base. Extremely rare are large-area forms. Malignant mixed tumours are very rare; if they occur, they usually metastasise to the regional lymph nodes, but also distant metastases.

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Embedded in myxoid or chondroid stroma, epithelial limited luminae are found. Depending on the form of the luminae, tubular and cystic, sometimes branching luminae are distinguished from small tubular luminae.

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  1. Gartmann H et al (1979) Chondroid syringoma. Z Hautkr 54: 908-913
  2. Deer P, Helwig EB (1961) Chondroid syringoma. Mixed tumor of skin, salivary gland type. Arch Dermatol 84: 835-847
  3. Mentzel T et al (2003) Cutaneous myoepithelial neoplasms: clinicopathologic and immunohistochemical study of 20 cases suggesting a continuous spectrum ranging from benign mixed tumor of the skin to cutaneous myoepithelioma and myoepithelial carcinoma. J Cutan Pathol 30: 294-302
  4. Salama ME et al (2004) Chondroid syringoma. Cytokeratin 20 immunolocalization of Merkel cells and reappraisal of apocrine folliculo-sebaceous differentiation. Arch Pathol Lab Med 128: 986-990
  5. Takahashi H et al (2004) Malignant chondroid syringoma with bone invasion: a case report and review of the literature. Am J Dermatopathol 26: 403-406
  6. Welke S et al (1982) The chondroid syringoma. dermatologist 33: 15-17
  7. Yavuzer R et al (2003) Chondroid syringoma: a diagnosis more frequent than expected. Dermatol Surge 29: 179-181


Please ask your physician for a reliable diagnosis. This website is only meant as a reference.


Last updated on: 29.10.2020