Syringocystadenoma papilliferum D23.L4

Author: Prof. Dr. med. Peter Altmeyer

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Last updated on: 29.10.2020

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Hidradenoma verrucosum fistulovegetans (Darier); papilliferous nevus syringoadenomatosus; papilliferous nevus syringocystadenomatosus

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Elliot, 1893

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Benign adnexal tumor with apocrine differentiation. About 1/3 of the cases are associated with a sebaceous nevus. Rarely the transition to an apocrine ductal carcinoma occurs.

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Especially the capillitium, face, neck, armpits, groins and genital region are affected.

Clinical features
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Mostly solitary, rarely multiple or linearly arranged, reddish-brown, 1.0-5.0 cm large tumor with predominantly verrucous, sometimes ulcerated surface.

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Usually moderately well defined dermal tumor originating from the surface epithelium with villi-shaped, papillary convolutes. These are lined in the upper part of the squamous epithelium, in the deeper parts by double-row cuboidal or cylindrical epithelium. Apocrine decapitation. In the deeper parts cystic dilated duct systems are visible. The centre of the papillae is densely filled with lymphocytes and plasma cells. Although plasma cell infiltration is a characteristic feature of this adnexal tumor, it is not specific and is also found in other apocrine differentiated tumors.

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Excision in toto is curative.

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  1. Aktepe F et al (2003) Tubular apocrine adenoma in association with syringocystadenoma papilliferum. Dermatol Online J 9: 7
  2. Askar S et al (2003) Syringocystadenoma papilliferum mimicking basal cell carcinoma on the lower eyelid: a case report. Acta Chir Plast 44: 117-119
  3. Boni R et al (2001) Syringocystadenoma papilliferum: a study of potential tumor suppressor genes. At J Dermatopathol 23: 87-89
  4. Castilla EA et al (2002) Trichilemmoma and syringocystadenoma papilliferum arising in naevus sebaceous. Pathology 34: 196-197
  5. Goshima J et al (2003) Syringocystadenoma papilliferum arising on the scrotum. Eur J Dermatol 13: 271
  6. Hsu PJ et al (2003) Mixed tubulopapillary hidradenoma and syringocystadenoma papilliferum occurring as a verrucous tumor. J Cutan pathogen 30: 206-210
  7. Li A et al (2003) Syringocystadenoma papilliferum contiguous to a verrucous cyst. J Cutan catholic 30: 32-36
  8. Patterson JW et al (2001) Linear syringocystadenoma papilliferum of the thigh. J Am Acad Dermatol 45: 139-141
  9. Pullmann H et al (1984) Syringosystadenoma papilliferum as differential diagnosis of a lower lip carcinoma. Z Hautkr 60: 348-355
  10. Yamamoto O et al (2003) An immunohistochemical and ultrastructural study of syringocystadenoma papilliferum. Br J Dermatol 147: 936-945


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Last updated on: 29.10.2020