Sulfadiazine
Synonym(s)
sulfapyrimidine
Definition
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Half-life
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13–24 h
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Indication
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Acute and recurrent toxoplasmosis in combination with pyrimethamine
Dosage and method of use
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- Adults: Initially 2-4 g, then every 4-6 hours 1 g p.o.
- Children: 65-150 mg/kg bw/day p.o.
Undesirable effects
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- Cutaneous ADRs (approx. 10-20% of patients): macular or papular exanthema, angioedema, erythema exsudativum multiforme, photosensitivity.
- Also: blood count changes (leukopenia, thrombocytopenia), drug fever, headache and joint pain, gastrointestinal side effects such as nausea, diarrhoea, flatulence, vomiting. Rarely cholestatic hepatosis. Hypoglycemia, kidney or liver damage. Very rarely transitory myopia.
Preparations
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sulfadiazine heyl
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Prof. Dr. med. Peter Altmeyer