Sebaceous hyperplasia senile D23.L

Author: Prof. Dr. med. Peter Altmeyer

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Last updated on: 29.10.2020

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Synonym(s)

Adenoma sebaceum senile; circumscribed senile sebaceous hyperplasia; sebaceous hyperplasia; sebaceous hyperplasia circumscribed senile; senile sebaceous nevus

Definition
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Etiopathogenesis
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Immunosuppression (e.g. after taking Ciclosporin) is beneficial.

Manifestation
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Occurs after the age of 35, especially in seborrhoics. Men are more frequently affected than women.

Localization
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Face, forehead, sides of the cheeks.

Clinical features
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Solitary, but mostly multiple, then disseminated, 0.2-0.5 cm in size, skin-coloured, yellowish-reddish or yellow, centrally always navelled(Cave! clinically important sign; DD basal cell carcinoma!), flat or calotte-shaped, smooth papules, which show a lobular structure and a shiny surface when viewed and illuminated laterally (and under reflected light microscopy).

Less frequently, 0.5-1.0 cm large, solitary papules or nodes with a mostly bumpy surface structure are found.

Mostly clear, accompanying seborrhoea oleosa with prominent skin pores.

Histology
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Symmetrical tumour protruding the mostly unchanged epidermis, in which mature, hyperplastic sebaceous gland lobules are grouped around a central, dilated infundibulum filled with horny and sebaceous masses. Pityrosporon oval or bacterial clusters are often found in the retinal masses.

Differential diagnosis
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Therapy
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In case of cosmetically disturbing lesions, treatment with laser (Erbium-Yag-Laser orCO2-Laser) or excision.

Note(s)
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Confluent sebaceous gland adenomas, which cover almost the entire neck and clavicle region, are to be considered as malformation. The nosological value of the diffuse presenile sebaceous gland hyperplasia remains to be seen.

Literature
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  1. Finan MC, Apgar JT (1991) Juxta-clavicular beaded lines: a subepidermal proliferation of sebaceous gland elements. J Cutan catholic 18: 464-468
  2. Kaufmann R (1987) Diffuse (presenile) sebaceous gland hyperplasia, a new entity? dermatologist 38: 31-35
  3. Zouboulis C et al (2003) Ciclosporin A - induced sebaceous glands hyperplasia. Br J Dermatol 149: 198-200

Disclaimer

Please ask your physician for a reliable diagnosis. This website is only meant as a reference.

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Last updated on: 29.10.2020