DefinitionThis section has been translated automatically.
Diseases from the classic "fibrotic" form, whereby systemic scleroderma (systemic sclerosis) can be regarded as a prototype of multisystem sclerosis. Circumscribed localized scleroderma is a mono-organic (skin) infection. The leading symptom of scleroderma is the fibrotic remodelling (sclerosis) of the skin.
ClassificationThis section has been translated automatically.
Basically one can distinguish:
- Circumscribed (or localized) scleroderma (Morphea); here the sclerotherapy is mainly limited to the skin, the subcutaneous fatty tissue and, with regard to localization, also to the underlying bone.
- Systemic scleroderma as a multi-organ disease with a progressive, potentially fatal course that affects not only the skin but also numerous internal organs (especially the digestive tract, lungs, heart and kidneys).
For differential diagnostic reasons, clinical pictures with a scleroderma-like aspect or course must be separated, the pseudoscleroderma.
TherapyThis section has been translated automatically.
LiteratureThis section has been translated automatically.
- Fabris M, Hunzelmann N (2007) Differential diagnosis of scleroderma and pseudoscleroderma. JDDG 11:977-984
- Kayser C et al(2015) Autoantibodies in systemic sclerosis: unanswered questions. Front Immunol 6:167
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