Scleroderma (overview) M34.9

Author: Prof. Dr. med. Peter Altmeyer

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Last updated on: 29.10.2020

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Synonym(s)

Scleroderma

Definition
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Diseases from the classic "fibrotic" form, whereby systemic scleroderma (systemic sclerosis) can be regarded as a prototype of multisystem sclerosis. Circumscribed localized scleroderma is a mono-organic (skin) infection. The leading symptom of scleroderma is the fibrotic remodelling (sclerosis) of the skin.

Classification
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Basically one can distinguish:

  • Circumscribed (or localized) scleroderma (Morphea); here the sclerotherapy is mainly limited to the skin, the subcutaneous fatty tissue and, with regard to localization, also to the underlying bone.
  • Systemic scleroderma as a multi-organ disease with a progressive, potentially fatal course that affects not only the skin but also numerous internal organs (especially the digestive tract, lungs, heart and kidneys).

For differential diagnostic reasons, clinical pictures with a scleroderma-like aspect or course must be separated, the pseudoscleroderma.

Therapy
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Literature
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  1. Fabris M, Hunzelmann N (2007) Differential diagnosis of scleroderma and pseudoscleroderma. JDDG 11:977-984
  2. Kayser C et al(2015) Autoantibodies in systemic sclerosis: unanswered questions. Front Immunol 6:167

Disclaimer

Please ask your physician for a reliable diagnosis. This website is only meant as a reference.

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Last updated on: 29.10.2020