Saquinavir
Definition
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Half-life
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10 h
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Pharmacodynamics (Effect)
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HIV protease inhibitor.
Indication
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Combination therapy of HIV infection.
Dosage and method of use
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Invirase: Adults and children > 16 years: 2 times/day 1000 mg (2 times 5 hard caps.) plus ritonavir 100 mg 2 times/day.
Notice! Saquinavir must be taken in the first 2 hours after a meal. Grapefruit juice increases the bioavailability of saquinavir by 40% if 150 ml is taken at the beginning of a meal and one hour later!
Undesirable effects
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Nausea, abdominal pain, fever, headache, weakness.
Interactions
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See Table 1.
Preparations
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Invirase
Literature
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- Eron JJ JR (2002) HIV-1 protease inhibitors. Clin Infect Dis 30: 160-170
Tables
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Key interactions of saquinavir
Clindamycin |
Clindamycin plasma levels ↑ |
Dapson |
Dapson plasma mirror ↑ |
Itraconazole |
Saquinavir plasma mirror ↑ |
Ketoconazole |
Saquinavir plasma mirror ↑ |
Phenytoin |
Saquinavir plasma mirror ↓ |
Rifabutin |
Saquinavir plasma mirror by 40% ↓ |
Rifampicin |
Saquinavir plasma mirror by 40% ↓ |
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Prof. Dr. med. Peter Altmeyer