HistoryThis section has been translated automatically.
Rudolf Happle, 1991
DefinitionThis section has been translated automatically.
Renbök is a palindrome of the word Köbner (see Köbner phenomenon below ). Rudolf Happle used the Renbök phenomenon to describe the so-called inverse Köbner effect. Patients with psoriasis and alopecia areata universalis exhibited normal hair growth in the area of the psoriasis lesions, i.e. the expression of one skin disease is suppressed by a second.
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General informationThis section has been translated automatically.
Note: The pathogenetic peculiarity of the immunological process underlying this phenomenon is unknown. In any case, a pre-existing dermatosis (psoriasis) causes protection against the appearance of another skin disease (alopecia areata). In other words, in the immunological rooming of the psoriatic lesion, a systemic autoimmunological reaction as in alopecia areata totalis cannot have an effect.
Another example is vitiligo and lichen planus
The extent to which this phenomenon can be regarded as an inverse "Köbner phenomenon" remains open.
A similar immune mechanism was induced by the artificial, now obsolete treatment of alopecia areata via contact sensitization using diphenylcyclopropenone (DPCP) (Harris JE et al. 2010). Here, too, 2 different immunological mechanisms neutralize each other.
EtiologyThis section has been translated automatically.
The exact immunological basis has not yet been conclusively clarified. It is assumed that the cytokine profiles of two diseases inhibit each other:
- Different T cell populations (e.g. Th1 vs. Th17) may compete locally for dominance.
- One disease sets local immunological conditions that exclude another disease.
LiteratureThis section has been translated automatically.
- Happle R et al. (1991) The Renbök phenomenon: An inverse Köebner reaction observed in alopecia areata. Eur J Dermatol 1: 39-40.
- Harris JE et al. (2010) Renbök Phenomenon and Contact Sensitization in a Patient with Alopecia Universalis. Archives of Dermatology. 146: 422-425.
Ito Tet al. (2010) Contact immunotherapy-induced Renbök phenomenon in a patient with alopecia areata and psoriasis vulgaris. European Journal of Dermatology 20: 126-127.
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Xing L et al. (2014) Alopecia areata is driven by cytotoxic T lymphocytes and is reversed by JAK inhibition. Nat Med 20:1043-1049.
